Beaumont Hospital Kidney Centre

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Our Medical Team

Consultants

Conall Headshot

Prof. Conall O'Seaghdha

(Co Clinical Director for Transplant Urology & Nephrology)

Specialty: General Nephrology and Transplantation Nephrology

 College of Graduation: University College Dublin and Harvard Medical School, Boston, USA.

Year of Graduation: 2000

Phone: (01) 809 2567 Public Clinic

Subspeciality interests: Kidney transplantation, chronic kidney disease, fluid and electrolyte disorders, inherited kidney disease.

Research Interests: Genetics of kidney disease in the general population, Genetics of familial kidney disease, Stratification of kidney disease risk in the general population, Identification of novel kidney disease biomarkers, Epidemiology of kidney disease in the community, Kidney transplant. 

Recent Publications

1.            O’Seaghdha CM, Yang, Glazer NL, Leak TS, Dehghan A, Smith AV, Kao WH, Lohman K, Hwang SJ, Johnson AD, Hofman A, Uitterlinden AG, Chen YD; The GEFOS Consortium, Brown EM, Siscovick DS, Harris TB, Psaty BM, Coresh J, Gudnason V, Witteman JC, Liu YM, Kestenbaum BR, Fox CS, Köttgen A. “Meta-analysis of genome-wide association studies identifies six new loci for serum calcium concentrations”. Plos Genetics; in press

 

2.            O’Seaghdha CM, Nicole L. Glazer, Ronit Katz, Mark Sarnak, David Siscovick, Bruce Psaty, Caroline S. Fox, Michael G. Shlipak on behalf of the CHARGE consortium. “Association of a cystatin C gene variant with cystatin C levels, chronic kidney disease, and risk of incident cardiovascular disease and mortality”. American Journal of Kidney Diseases; in press

 

3.            O’Seaghdha CM, Hwang SJ, Ho JE, Ramachandran VS, Levy D, Fox CS. “Elevated galectin-3 precedes the development of chronic kidney disease” Journal of the American Society of Nephrology; in press

 

4.            O’Seaghdha CM, Hwang SJ, Larson MG, Ramachandran VS, Fox CS “A Urinary Biomarker Panel, Incident Kidney Disease and Clinical Outcomes” Journal of the American Society of Nephrology; in press

 

5.            Matthias Olden, Alexander Teumer, Cristian Pattaro, Anna Köttgen, Stephen T. Turner, Murielle Bochud, Abbas Dehghan, Francois Bastardot, Rainer Rettig, Reinhold Schmidt, Peter Vollenweider, David Siscovick, Daniel Levy, Josef Coresh,  Linda Kao, Caroline S. Fox, and O'Seaghdha CM “Minimal overlap in common genetic polymorphisms underpinning renal functional traits and vascular disease phenotypes” American Journal of Kidney Diseases; 2013 Jun;61(6):889-898.

 

6.            Anna Köttgen, Eva Albrecht, Alexander Teumer, Veronique Vitart, Jan Krumsiek, Claudia Hundertmark, Giorgio Pistis, Daniela Ruggiero, O’Seaghdha CM, Toomas Haller, Qiong Yang, Toshiko Tanaka, Andrew D Johnson, Zoltán Kutalik, Albert V Smith, Julia Shi, Maksim Struchalin…. Daniel I Chasman, Olli Raitakari, WH Linda Kao, Marina Ciullo, Caroline S Fox, Mark Caulfield, Murielle Bochud, Christian Gieger. “Multiple Novel Loci Highlighting Metabolic Control of Urate Production and Excretion are Associated with Gout” Nature Genetics; 2013 Feb;45(2):145-54.

 

7.            Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA,  Endlich K, Olden M, Chen M, Tin A, Taliun D, Li M, Gao X, Gorski M,Yang Q, Hundertmark C, Foster MC, O’Seaghdha CM… Bochud M, Heid IM, Kao WL, Fox CS, Kottgen AK. “Integration of Genome-Wide Association Studies with Biological Knowledge Identifies Six Novel Genes Related to Kidney Function” Human Molecular Genetics; 2012 Dec 15;21(24):5329-43.

 

8.            O’Seaghdha CM, Shih-Jen Hwang, Rachel Holden, Sarah L. Booth, Caroline S. Fox. “Phylloquinone and Vitamin D Status: Associations with Incident Chronic Kidney Disease in the Framingham Offspring Cohort”. American Journal of Nephrology; 2012;36(1):68-77.

 

9.            Ellis JW, Böger CA, Bochud M, Chen M, de Andrade M, de Boer I, Kao WH, Köttgen A, Leak TS, Parsa A, Smith AV, Fox CS, O'Seaghdha CM. “Association of Common GFR Loci with Albuminuria in Individuals of European Descent”. Human Molecular Genetics 2012; doi: 10.1093/hmg/dds138

 

10.          Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, ...Goessling W, Chasman DI, Kao WH, Fox CS. “Genome-wide Association and Functional Follow-Up Reveal New Loci for Kidney Function” PLoS Genetics; 2012 Mar;8(3):e1002584.


Peter Conlon

Prof. Peter Conlon

Specialty: General Nephrology and Transplantation Nephrology.

College of Graduation: Royal College of Surgeons in Ireland and Duke University Medical Centre, USA.

Year of Graduation: 1986

Phone: (01) 809 2747 Public Clinic

              (01) 837 9311 Private Clinic

Clinical Interests: All aspects of kidney transplantation, renal vascular disease, inherited kidney disease.

Research Interests: Kidney transplant outcomes, Role of genetics in inherited renal syndromes, Renal vascular disease.

 

Recent Publications

1. Paul J. Phelan, Peter J. Conlon & Matthew A. Sparks. Genetic Determinants of Renal Transplant Outcome: Where do we stand? Journal of Nephrology Feb 2014 (DOI 10.1007/s40620-014-0053-4)

 

2. O'Brien FJ, Danapal M, Jairam S, Lalani AK, Cunningham J, Morrin M, McNally S, Donovan MG, Little D, Tuthill A, Conlon PJ. Manifestations of Von Hippel Lindau Syndrome: A retrospective national review. QJM Advance Access published December 17, 2013

 

3. Frank J. O’Brien, Ahad Abdalla, Limy Wong, Carol A. Traynor, Paul Cheriyan, Hong Kwan Kok, Liam Casserly,  Anthony Dorman, and Peter J. Conlon.Recurrence of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in Appropriately Immunosuppressed Renal Transplant Patients: A Discussion of Two Cases. Nephrol Urol 2013;3:16–21

 

4. Omer A. Raheem1, Padraig J. Daly1, Patrick O’Kelly1, William P. Shields1, Antonio J. Zimmerman1, Ponnusamy Mohan1, Richard Power1, Dilly M. Little1, Peter J. Conlon2 andDavid P. Hickey. Mycophenolate mofetil in low-risk renal transplantation in patients receiving no cyclosporine: a single-centre experience. Nephrol Dial Transplant (2012) 27: 840–844

 

5. Frank J. O’Brien, Hong Kuan T. Kok, Claire O’Kane, Johanna McWilliams, Patrick O’Kelly, Paula Collins, Joseph Walshe, Colm C. Magee, Mark D. Denton and Peter J. Conlon. Arterio-venous fistula buttonhole cannulation technique: a retrospective analysis of infectious complications. Clin Kidney J (2012) 5: 526–529

 

6. Paul J. Phelan, Patrick O'Kelly, Munir Tarazi, Nadim Tarazi, M. Ridhwaan Salehmohamed, Dilly M. Little, Colm Magee and Peter J. Conlon. Renal allograft loss in the first post-operative month: causes and consequences. Clin Transplant 2012 DOI: 10.1111/j.1399-0012.2011.01581.x

 

7. C. Traynor, A. Jenkinson, Y. Williams, P. O’Kelly , D. Hickey, M. Denton, C. Magee and P. J. Conlon. Twenty-Year Survivors of Kidney Transplantation. Clin Kidney J (2012) 5: 526–529.

 

8. Talat H. Malik, Peter J. Lavin, Elena Goicoechea de Jorge, Katherine A. Vernon,Kirsten L. Rose, Mitali P. Patel, Marcel de Leeuw, John J. Neary, Peter J. Conlon, Michelle P. Winn, and Matthew C. Pickering. A Hybrid CFHR3-1 Gene Causes Familial C3 Glomerulopathy. J Am Soc Nephrol 23: 2012.

 

9. P.J. Phelan, P. O'Kelly, D. O'Neill, D. Little, D. Hickey, M. Keogan, J. Walshe, C. Magee, P.J. Conlon. Immediate re-transplantation following early kidney transplant thrombosis. Clin Transplant 2009,1399-1412.

 

10. P.J. Phelan, J.J. Walshe, A. Al-Aradi, J.P. Garvey, K. Finnegan, P. O’Kelly, J. McWilliams, J.P. Ti, M.M. Morrin, N. Morgan and P.J. Conlon. Encapsulating peritoneal sclerosis: experience of a tertiary referral center. Renal Failure, 32, 459–463, 2010.

 

11.  Paul J. Phelan, Rory K.J. Murphy, Michael Farrell, Orna O’Toole, Josie Heffernan,Donncha O’Brien, Oscar Breathnach and Peter J. Conlon. EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma? Nephrol Dial Transplant (2010) 1 of 4.

 

12. P.J. Phelan, P. O'Kelly, D. O'Neill, D. Little, D. Hickey, M. Keogan, J. Walshe, C. Magee, P.J. Conlon. Analysis of waiting times on Irish renal transplant list. Clin Transplant 2009,1399-1412.

 


Colm Magee

Dr Colm Magee

Specialty: Nephrology and Kidney Transplantation

College of Graduation: Royal College of Surgeons Ireland

Year of Graduation: 1991

Phone: (01) 797 4701 Public Clinic

              083 379 4565 Private Clinic

Subspeciality interests:  All forms of kidney disease but particular interest in renal transplantation, in cancer-associated kidney disease and in kidney diseases associated with pregnancy.

 
Dr Denton

Dr Mark Denton

Specialty: Nephrology

College of Graduation: Edinburgh University Medical School, Kings College Hospital London and Harvard Medical School Boston.

Qualifications: BSc PhD MRCP

Year of Graduation: 1991, 2001.

Phone: (01) 809 3080 Public Clinic

Subspeciality interests: Transplant Nephrology, Peritoneal Dialysis, Haemodialysis.
 

Recent Publications

 


DF Pic

prof. Declan de Freitas

Specialty: Renal Medicine

College of Graduation: Royal College of Surgeons in Ireland

Year of Graduation: 2000

Qualifications: MB BAO BCH LRCP&SI PhD 

Phone: (01) 809 3357 Public Clinic 

             Private secretary (Beaumont Private Clinic): Julie at 025 86315

Subspeciality interests:  Kidney transplantation (transplant rejection and infectious diseases); Acute Kidney Injury; Chronic Kidney Disease; Glomerular Diseases; Peritoneal Dialysis; Haemodialysis; Renal Stone Disease; Electrolyte disorders; Inherited kidney Diseases

 

Recent Publications

.

1.      Sellarés J, Reeve J, Loupy A, Mengel M, Sis B, Skene A, de Freitas DG, Kreepala C, Hidalgo LG, Famulski KS, Halloran PF. Molecular diagnosis of antibody-mediated rejection in human kidney transplants. Am J Transplant. 2013 Apr;13(4):971-83

2.      Famulski KS, Reeve J, de Freitas DG, Kreepala C, Chang J, Halloran PF.Kidney transplants with progressing chronic diseases express high levels of acute kidney injury transcripts. Am J Transplant. 2013 Mar;13(3):634-44

3.      Reeve J, Sellarés J, Mengel M, Sis B, Skene A, Hidalgo L, de Freitas DG, Famulski KS, Halloran PF. Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies. Am J Transplant. 2013 Mar;13(3):645-55

4.      Famulski KS, de Freitas DG, Kreepala C, Chang J, Sellares J, Sis B, Einecke G, Mengel M, Reeve J, Halloran PF. Molecular phenotypes of acute kidney injury in kidney transplants. J Am Soc Neph 2012; Feb 16: Epub ahead of print

5.      Sis B, Jhangri GS, Riopel J, Chang J, de Freitas DG, Hidalgo L, Mengel M, Matas A, Halloran PF. A new diagnostic algorithm for antibody-mediated microcirculation inflammation in kidney transplants. J Am Soc Nephrol. 2012 May;23(5):948-58

6.      Sellares J, de Freitas DG, Mengel M, Reeve J, Einecke G, Sis B, Hidalgo LG, Famulski K, Matas A, Halloran PF. Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence. Am J Transplant 2012; 12(2): 388-399

7.      de Freitas DG, Sellares J, Reeve J, Chang J, Hidalgo LG, Famulski KS, Mengel M, Sis B, Einecke G, Halloran PF. The nature of biopsies with "borderline rejection" and prospects for eliminating this category. Am J Transplant 2012; 12(1): 191-201

8.      Sellares J, de Freitas DG, Mengel M, Sis B, Hidalgo L, Matas A, Kaplan B, Halloran PF. Inflammation lesions in kidney transplant biopsies: Association with survival is due to the underlying diseases. Am J Transplant 2011; 11(3): 489-499

9.      Mengel M, Chang J, Kayser D, Gwinner W, Schwarz A, Einecke G, Broecker V, Famulski K, de Freitas DG, Hidalgo L, Sis B, Haller H, Halloran PF. The molecular phenotype of six-week protocol biopsies from human renal allografts: Reflections of prior injury but not future course. Am J Transplant. 2011; 11(4): 708-718

10.  Halloran PF, de Freitas DG, Einecke G, Famulski K, Hidalgo L, Mengel M, Reeve J, Sellares J, Sis B. An integrated view of molecular changes, histopathology and outcomes. Am J Transplant 2010; 10(10): 2223-30

11.  Halloran PF, de Freitas DG, Einecke G, Famulski K, Hidalgo L, Mengel M, Reeve J, Sellares J, Sis B. The molecular phenotype of kidney transplants. Am J Transplant. 2010; 10(10): 2215-22.

12.  Mengel M, Sis B, Kim D, Chang J, Famulski K, Hidalgo L, Einecke G, de Freitas DG, Tymchak W, Burton J, Halloran PF. The molecular phenotype of heart transplant biopsies: Relationship to histopathological and clinical variables. Am J Transplant. 2010 Sep; 10(9):2105-15.

13.  de Freitas D, Picton M. Clinical assessment of renal function. Anaesthesia and Intensive Care Medicine 2009; 10(6):293-295

14.  de Freitas DG, Augustine T, Hurst H, Taylor P, Williams R, Hutchison A, Brenchley PEC, Summers AM. Encapsulating peritoneal sclerosis following renal transplantation despite Tamoxifen and immunosuppressive therapy. NDT Plus 2008; 1(5):333-335

15.  de Freitas DG, Jordaan A, Alderdice J, Curwell J, Hurst H, Hutchison AJ, Brenchley PEC, Augustine T, Summers AM. Nutritional management of patients undergoing surgery following diagnosis with encapsulating peritoneal sclerosis. Perit Dial Int. 2008 May-Jun; 28(3):271-6.

16.  de Freitas DG, Donne R, Hutchison AJ. Lanthanum carbonate – a first line phosphate binder. Semin Dial. 2007 Jul-Aug; 20(4):325-8

17.  Jordaan A, de Freitas DG, Hurst H, Alderdice J, Curwell J, Brenchley PEC, Hutchison AJ, Summers AM. Malnutrition and refeeding syndrome in a patient with encapsulating peritoneal sclerosis. Perit Dial Int. 2007 Jan-Feb; 27(1):100-1

18.  de Freitas DG, Venning M. Cancer and the Kidney-Book Review. Surgical Oncology 14 (2005) 145 

19.  de Freitas DG, Gokal R. Sterile peritonitis in the peritoneal dialysis patient. Perit Dial Int. 2005 Mar-Apr; 25(2):146-51.

20.  Maloney FJ, de Freitas D, Conlon PJ, Murphy GM. Renal transplantation, immunosuppression and the skin: an update. Photodermatol Photoimmunol Photomed. 2005 Feb; 21(1): 1-8.

 

Dr Declan de Freitas MB PhD

Consultant Nephrologist and Transplant Physician

 



Mark Little

Prof. Mark Little

Specialty: Nephrology/Vasculitis

College of Graduation: Trinity College Dublin

Year of Graduation: 1993

Phone: (01) 809 2567 Public Clinic

Subspeciality interests: Biomarkers of disease, Anti-Neutrophil Cytoplasmic Antibodies, Crescentic Glomerulonephritis, Immune-Complex Glomerulonephritis, Inflammation, Neutrophil Adhesion, System Vasculitis