Beaumont Hospital

Print Print Page | A | A | A

Endocrinology and Diabetes Research

Endocrinology Research

The unit has developed an international reputation in research into pituitary disease.  It is considered a world leader in research on pituitary dysfunction following traumatic brain injury and cranial radiotherapy. It is a key international opinion leader in the endocrine control of water balance. Our department publishes on these topics in the leading scientific journals in the field such as JAMA, The American Journal of Medicine and the Journal of Clinical Endocrinology and Metabolism. Professor Thompson, Dr Agha and Dr Smith are regularly invited to address national and international meetings and medical societies reflecting the high profile of the unit nationally and internationally.

Currently, Dr Lucy Ann Behan is carrying out  research for her MD thesis on glucocorticoid replacement therapy in hypopituitary patients.  Dr. Mark Hannon has started an MD research project on salt and water imbalance after subarachnoid haemorrhage. Dr Colin Davenport is working on the role of a novel bone glycoprotein called osteoprotegerin in diabetic vascular disease, this work is in collaboration with the non-invasive vascular laboratory and Dr Patricia Fitzgerald.

Dr. Francis Finucane and our unit have won the prestigious IJMS/RAMI award for 2008 for the best published paper in the category of Endocrinology and Diabetes (Dr Rachel Crowley from our department was also short-listed for the award). In 2007, Professor Thompson won the same award for the best published paper in the Irish Journal of Medical Sciences. In 2007, Dr Behan won the Montgomery’s medal from the Irish Endocrine Society.  

Diabetes Research

The Diabetes Department in Beaumont Hospital is a very busy clinical service looking after over 6,500 patients with both type 1 and 2 diabetes. The research interests are diverse and include the investigation and treatment of hypoglycaemia, the use of continuous glucose monitoring systems and subcutaneous insulin infusion pumps.

In collaboration with Dr Patricia Fitzgerald in the non-invasive vascular unit in Beaumont Hospital and the School of Human Health and Performance in Dublin City University, we are currently investigating the role of a glycoprotein called osteoprotegerin in diabetic vascular disease.  Other interests include work on the role of hyperglycaemia in cystic fibrosis in collaboration with the Cystic Fibrosis department in the Hospital.

Consultant Endocrinologists

  • Prof Christopher Thompson
  • Dr Diarmuid Smith
  • Dr Amar Agha

Sample Publications (Endocrinology and Diabetes, 2007-2008)

Schneider HJ, Kreitschmann-Andermahr I, Ghigo E , Stalla GK,  Agha A. (2007)  Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid haemorrhage. JAMA  298:1429-1437

Crowley R, Smith D, Agha A, Sherlock M, Thompson CJ. (2007) Clinical insights into adipsic diabetes insipidus: a large case series. Clinical Endocrinology 66: 475-82.

Moore KB, McKenna K, Osman M, Tormey WP, McDonald D, Thompson CJ. (2007)
Atrial natriuretic peptide increases urinary albumin excretion in people with
normoalbuminuric type-2 diabetes. Ir J Med Sci., 176(2):67-73. 

Agha A, Phillips J, Thompson CJ. (2007) Pituitary dysfunction following traumatic brain injury. British Journal of Neurosurgery 21: 210-216.

Behan LA, Agha A. (2007) Endocrine Consequences of Adult Traumatic Brain Injury". Hormone Research, 68, S5: 18 - 21.

O’Malley G, Moran C, Draman MS, King T, Smith D, Thompson C, Agha A. (2007).
Central Pontine Myelinolysis complicating Treatment of the Hyperglycaemic Hyperosmolar State (HHS). Annals of Clinical Biochemistry, 45:440-443.

Moran C,  Behan LA, King T, Draman MS, Smith D, Sreenan S, Thompson CJ, Agha A.  (2008) Spontaneous recovery from severe cardiac failure after acute hypotensive  infarction of a somatotroph adenoma. Clinical Endocrinology, 68: 321-322.

Liew A, Thompson CJ.  (2008) Is hypopituitarism predictable after traumatic brain injury?  Nat Clin Pract Endocrinol Metab., 4:126-127.

Finucane FM,   Liew A, Thornton E,  Rogers E, Tormey W, Agha A.  (2008) Clinical Insights into the Safety and Utility of the Insulin Tolerance Test (ITT) in the assessment of the Hypothalamopituitary-adrenal axis. Clinical Endocrinology , 69:603-607.

Behan LA, Phillips J, Thompson CJ, Agha A. (2008)  Neuroendocrine disorders after traumatic brain injury. Journal of Neurology, Neurosurgery and Psychiatry, 79:753-759.